Published 1999 Full Text View/download PDFĬan estrogen keep you smart? Evidence from clinical studies.Ĭoull, J. Since AEA and R-methanandamide are structurally similar to arachidonic acid, they may interact with the mAChR in a similar manner to inhibit receptor function. This demonstrates that mAChR inhibition by the anandamides is not mediated by the cannabinoid receptor. Further, the cannabinoid agonist WIN 55212-2 does not alter antagonist binding to the mAChR. The cannabinoid antagonist SR141716A did not alter AEA or R-methanandamide inhibition of NMS binding to the mAChR, even at concentrations as high as 1 µ M. Both AEA and R-methanandamide stimulate mAChR binding of the agonist oxotremorine-M at low concentrations (25–75 µ M), but significantly inhibit agonist binding at higher concentrations (I 50=150 µ M). R-methanandamide inhibits more than 90% of both QNB binding (I 50=34 µ M) and NMS binding (I 50=15 µ M) to the mAChR. Binding of the more polar antagonist scopolamine (NMS) is inhibited by AEA up to 76% (half-maximal inhibition at 44 µ M). Binding of the mAChR antagonist quinuclidinyl benzilate (QNB) is inhibited up to 89% by AEA (half-maximal inhibition at 50 µ M). Two agonists of the cannabinoid receptor derived from arachidonic acid, anandamide (AEA) and R-methanandamide, inhibit ligand binding to the mAChR. The human brain muscarinic acetylcholine receptor (mAChR), which is involved in memory function and is inhibited by arachidonic acid, is also inhibited by anandamides. Loss of memory and cholinergic transmission are associated with both Alzheimer’s disease (AD) and marijuana use. Lagalwar, Sarita, Bordayo, Elizabeth, Hoffmann, Karen, Fawcett, John, and Frey, William Abstract Published 1999 Full Text View/download PDFĪnandamides inhibit binding to the muscarinic acetylcholine receptor. The implications of these findings to problem diagnosis and decision aids are discussed. These findings are considered to be consistent with an editing account of the part-set cueing phenomenon. When prompts consist of high plausibility or low severity hypotheses, no inhibition is observed. Inhibition is significant when prompts contain low plausibility hypotheses that are also high in severity. However, the results from the experiments reveal an asymmetric inhibition effect. The results show that part-set cueing effects occur during hypothesis generation and that they are robust to changes in the symptoms. Experiment 3 extends the findings of the first two experiments to hypothesis generation and discriminates between competing accounts for the part-set cueing effect. Experiment 2 examines whether the part-set cueing effect is sensitive to changes in the symptoms that drive the diagnosis and whether differences in inhibition occur because of prompt plausibility or because of target plausibility. Experiment 1 examines whether part-set cueing affects the ability of auditors to recall diagnoses, and if so, whether memory inhibition is affected by the plausibility of the hypotheses. The aim of this research is to examine the generality of the part-set cueing effect, a well-known memory-inhibition phenomenon in basic research, to professional problem diagnosis. Subjects AUDITORS, ACCOUNTING firms, MEMORY, HYPOTHESIS, PROBLEM solving Abstract Part-Set Cueing Effects in a Diagnostic Setting with Professional Auditors. Published 1999 Full Text View/download PDF Tendency to depression was observed anxiety levels were normal. In the absence of global intellectual deterioration, the patients had a deficit: a) in learning and verbal long-term memory tasks and in visual long-term memory of complex figure b) in timed tasks, accounted for by a slowness of mental processes c) in tasks with a motor component. They were compared to healthy volunteers, matched for age and education. Moved by the lack of information about cognitive dysfunction of Brazilian MS patients, the present study attempted to describe features of neuropsychological alterations in patients with relapsing remitting MS living in the city of São Paulo. Multiple sclerosis (MS) is a common disease in Western countries of temperate/cold climate, but in tropical countries an increasing number of cases have been diagnosticated. MIRANDA Subjects multiple sclerosis, relapsing remitting, neuropsychological evaluation, memory, cognition, Neurosciences.
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